CHEMICAL APPROACHES FOR STUDYING THE BIOLOGY AND PHARMACOLOGY OF MEMBRANE TRANSPORTERS: THE HISTIDINE/LARGE AMINO ACID TRANSPORTER SLC7A5 AS A BENCHMARK

The localization of membrane transporters at the forefront of natural barriers makes these proteins very interesting due to their involvement in the absorption and distribution of nutrients and xenobiotics, including drugs.Over the years, structure/function relationship studies have been performed employing several strategies, including chemical mo

BackgroundBody size, nutrition and socioeconomic position (SEP) in early life have been associated with a wide range of long-term health effects.Epigenetics is one possible mechanism through which these early life exposures can impact later life health.We conducted a systematic review examining the observational evidence for the impact of body size

Phenols represent an important class of compounds that present high antimicrobial potential.The seventeen selected phenols were tested in vitro for their antimicrobial activity showing different activity to S.aureus ATCC 25923, E.coli ATCC 25922, P.aeruginosa ATCC 27853 and C.albicans ATCC 90028.Most of the phenolic compounds have a good efficacy o

The subject of the research are the materials of judicial practice (texts of court decisions and Left Crank Arm information sources, the content of information about the results of court hearings), data from sociological surveys.The purpose of the article is to identify the relationship between the knowledge of municipal law, local self-government

The MM-015 trial assessed the Baby Feeding effect of lenalidomide-based therapy on health-related quality of life.Patients (n=459) with newly diagnosed multiple myeloma aged 65 years or over were randomized 1:1:1 to nine 4-week cycles of lenalidomide, melphalan, and prednisone, followed by lenalidomide maintenance; or lenalidomide, melphalan, and p